"They're the person to please never mind all the rest
for they're with you clear up to the end
And you've passed your most dangerous difficult test
if the person in the glass is your friend"
Depending on your personal life and interactions, you may feel like there are a ton of people you need approval from and to make happy, or just your loved ones. I don't disagree, if you love your family with all you have, and they love you too and just want the best for you, of course you want to get their approval and make them happy.
However, their feelings and happiness must come second to your inner personal happiness. Maybe you're working a job you hate and it is killing you slowly everyday, that you have to go into the office or log into work. But you are married, have kids or others that depend on you and the life you provide makes them happy and they approve of what you're doing right now. The question is, do they know how you are feeling? Most likely not, because most people in your shoes don't share those kind of feelings. By not sharing these feelings with those we care about, we are hurting ourselves.
I don't advise that you just up and quit your profession, but you can take things slowly. If you already know your passion and want to do something about it, like create your own business to expand on your idea, take it at your own pace. Pay for your business license in your state, purchase a couple of books on small businesses, learn at your pace, and take it all in, one step at a time.
You will find that, the excitement being generated by you following your passion, even if it is one step at a time and at your own pace, will start to overcome your pain that you experience everyday. It will breathe new life into you, and trust me, the change you will go through, will be seen by those you care for, and that will make them happy. So in the end you are killing two birds with one stone. You are making them happy because they are seeing a positive change in you, and you've started to pass your most dangerous difficult test by getting the person in the mirror to start becoming your best friend.